ABSTRACT
Wolfram syndrome is a relatively unexplored entity in clinical psychiatry. Historically, the discovery of a specific WFS1 gene had generated huge fanfare regarding specific genetic causations of psychiatric disorders. While the initial enthusiasm has faded now, association of Wolfram syndrome with psychiatric illnesses like schizophrenia, psychosis and suicidal behavior still remain important for understanding biological underpinnings of such disorders. We report a case of Wolfram syndrome presenting with multiple manic episodes, discuss possible genetic underpinnings for the affective symptoms and then discuss certain issues regarding management.
Subject(s)
Affective Symptoms , Bipolar Disorder , Comorbidity , Psychotic Disorders , Schizophrenia , Wolfram SyndromeABSTRACT
Dermatitis artefacta lies in a gray zone, between the specialities of psychiatry and dermatology. The condition could mimic a number of other lesions and therefore is a source of much confusion in clinical practice. Here, we describe a case of dermatitis artefacta in an 11-years old girl, which resembled self-harming behavior in Borderline personality disorder. We then discuss how the two could be differentiated and why this becomes imperative while dealing with such cases.
Subject(s)
Female , Humans , Borderline Personality Disorder , Dermatitis , Dermatology , Self-Injurious Behavior , SkinABSTRACT
While fluoxetine (FXT) is a frequently prescribed selective serotonin reuptake inhibitor (SSRI), with few major side-effects; altered serotonergic transmissions in hypothalamic pathways might lead to a distressing, and often embarrassing, manifestation of galactorrhea by altering prolactin release in those on FXT. We report here a case of FXT-induced hyperprolactinemic galactorrhea developing late into treatment on a stable regimen, who responded well to subsequent replacement with sertraline. Based on present finding, we suggest that while SSRIs may share similar mechanisms of action, there exist individual differences in their effects on prolactin secretion pathways.
Subject(s)
Female , Pregnancy , Fluoxetine , Galactorrhea , Hyperprolactinemia , Individuality , Obsessive-Compulsive Disorder , Prolactin , Secretory Pathway , Serotonin , Selective Serotonin Reuptake Inhibitors , SertralineABSTRACT
No abstract available.